Vitamin D at Kalusugan ng Musculoskeletal Impormasyon

Ano ito

Ang Vitamin D ay isang nutrient na kailangan ng iyong katawan upang bumuo at mapanatili ang buto. Ginagawa ito ng iyong balat mula sa sikat ng araw, at nakukuha mo rin ito mula sa ilang pagkain at supplement. Kapag mababa ang iyong levels, tinatawag itong vitamin D deficiency.

Mahalaga ang mababang vitamin D para sa mga buto at kasukasuan. Iniugnay ito sa mas mataas na pagkakataon ng ilang ligament tears sa tuhod, at sa mas mataas na pagkakataon na mabigo ang isang reconstructed ligament [1]. Iniugnay din ito sa mga stress fracture, kaya madalas sinusuri ang levels sa mga taong may mas mataas na panganib sa mga pinsalang ito [2]. Sa mga nakatatanda, mahalaga ang mababang vitamin D para sa kalusugan ng buto pagkatapos ng isang fracture mula sa simpleng pagkahulog [3].

Maaaring suriin ng iyong doktor ang iyong vitamin D sa panahon ng operasyon. Ang mababang levels bago ang operasyon ay iniugnay sa mas mabagal na paghilom ng sugat at sa ilang komplikasyon pagkatapos ng joint replacement [4] [5]. Ang pagsusuri nang maaga ay nangangahulugang ang deficiency ay maaaring matukoy at magamot, sa halip na makaligtaan [6].

Kasalukuyan pa ring pinag-aaralan kung paano ito nakakatulong. Ang Vitamin D ay may papel sa kung paano gumagaling ang buto at kung paano kumikilos ang immune system. Maaari rin itong sumuporta sa paghilom ng tendon, bagaman ang pananaliksik hanggang ngayon ay maliit at limitado sa isang grupo ng tendon [7]. Hindi lahat ng katanungan ay may malinaw na sagot pa. Halimbawa, ang ebidensya sa kasalukuyan ay hindi sumusuporta sa routine vitamin D supplementation para sa bawat pasyenteng sumasailalim sa knee replacement [8], at ang routine testing para sa bawat rotator cuff repair ay hindi binibigyang-katwiran ng mga kasalukuyang review [9].

Sa madaling salita, ang vitamin D ay isang bagay na kailangan ng iyong katawan, at ang mababang levels ay isang risk factor na maaaring matukoy sa pamamagitan ng simpleng blood test at magamot. Kung ito ay mahalaga para sa iyo ay depende sa iyong kalusugan, sa iyong nakaplanong gamutan, at sa iyong levels.

Gumagana ba ito?

Ang tapat na sagot ay depende ito sa kung ano ang inaasahan mong gagawin ng vitamin D.

Para sa mga buto, pinakamalinaw ang sitwasyon. Sa mga kababaihang postmenopausal na may osteoporosis, ang pag-inom ng calcium at vitamin D nang magkasama ay nagpahusay sa bone density sa pelvis at nagtama sa mababang antas nito sa dugo [1]. Ngunit natuklasan sa parehong pananaliksik na hindi nito nabawasan ang pagkakataon ng pagkabali ng buto [1]. Kaya nakatutulong ito upang magmukhang mas mabuti ang buto sa scan, ngunit hindi ito nagresulta sa mas kaunting fractures sa mga trials na ginawa hanggang ngayon.

Pagdating sa operasyon, magkahalo ang mga resulta. Ang mababang vitamin D bago ang operasyon ay naiugnay sa mga komplikasyon pagkatapos ng shoulder replacement, at ito ay isang bagay na maaaring gamutin bago ang operasyon [2]. Ngunit ang pagbibigay ng isang malaking dose ng vitamin D sa araw ng knee replacement surgery ay hindi nagpabago sa kung gaano kabilis ang paggaling ng mga pasyente, kung gaano kabilis silang nakagalaw, o sa kanilang complication rates kumpara sa isang placebo [3]. At para sa rotator cuff repair, isang review ang nagkonkludo na walang sapat na ebidensya upang bigyang-katwiran ang pag-test at pag-supplement sa bawat pasyente [4].

May mga tunay na puwang sa pananaliksik. Marami rito ay maliit lamang, at ang ilang mga natuklasan ay nagmula sa mga pag-aaral sa hayop sa halip na mga trial sa mga tao [5]. Patuloy pa ring inaalam ng mga mananaliksik kung sino ang nakikinabang sa pag-test, sino ang nakikinabang sa gamutan, at kung gaano ba talaga kahalaga ang vitamin D para sa paggaling pagkatapos ng operasyon.

Simple lang ang ibig sabihin nito para sa iyo. Mahalaga ang Vitamin D para sa kalusugan ng buto, at ang mababang antas nito ay dapat hanapin at itama. Ngunit hindi ito isang napatunayang paraan upang mas mapabuti ang operasyon o mapabilis ang paggaling ng mga sugat, at hindi sinusuportahan ng ebidensya ang awtomatikong pagbibigay nito sa lahat. Gagamitin ng iyong doktor ang iyong sariling kalusugan, ang iyong nakaplano na gamutan, at ang mga resulta ng iyong blood test upang magpasya kung ito ay kailangan para sa iyo.

Ano ang mga panganib?

Ang paggamot gamit ang Vitamin D ay hindi walang panganib, at ang tapat na katotohanan ay may mga bagay na gumagana at mayroon namang hindi.

Ang pinakakaraniwang problema ay ang paggamot na hindi gumagana nang kasing husay ng inaasahan. Sa isang pag-aaral sa mga pasyenteng sumailalim sa knee replacement, 33.7% lamang ng mga may mababang antas ang nakaabot sa normal na antas, kahit na may medium-to-high dose supplementation [1]. Ang pagbibigay ng isang malaking dose sa araw ng knee replacement surgery ay hindi nagpabago sa recovery, kung gaano kabilis nakagalaw ang mga pasyente, o sa rate ng mga komplikasyon kumpara sa isang placebo [2]. At para sa rotator cuff repair, natuklasan sa isang review na ang ebidensya ay hindi nagbibigay-katwiran sa pag-test at pag-supplement sa bawat pasyente [3].

Mayroon ding mga limitasyon sa kung ano ang kayang gawin ng vitamin D. Sa mga postmenopausal women na may osteoporosis, ang calcium at vitamin D nang magkasama ay nagpahusay sa bone density sa pelvis ngunit hindi nagbawas sa pagkakataon ng pagkabali ng buto [4]. Ang vitamin D status lamang ay maaaring hindi magpabago sa iyong agarang recovery pagkatapos ng surgery, bagaman ang pagpapanatili ng sapat na antas ay maaaring makatulong sa long-term survival pagkatapos ng hip fracture surgery [5].

Ang ilang mga natuklasan ay nagmula sa mga pag-aaral sa hayop sa halip na mga trial sa tao, kaya hindi ito maaaring direktang ilapat sa iyo [6]. Ang ebidensya sa tendon healing ay limitado lamang sa isang tendon group at ang mga pag-aaral ay may mababang kalidad [7]. Wala ring mabuting data sa kaligtasan at efficacy para sa mga peptide supplement, kaya hindi sila inirerekomenda bilang kapalit o dagdag sa standard orthopaedic care [8].

Ang ibig sabihin nito para sa iyo ay sulit na suriin at gamutin ang vitamin D kapag mababa ang mga antas nito, ngunit hindi ito isang garantisadong lunas. Titimbangin ng iyong doktor ang ebidensya laban sa iyong sariling sitwasyon bago ito irekomenda.

Tama ba ito para sa iyo?

Ang gamutan ng Vitamin D ay karaniwang angkop sa mga taong mababa ang level nito at mga sasailalim sa operasyon o nagpapagaling mula sa isang fracture. Ang regular na supplementation ay nagbabawas ng pagkakataon ng deficiency sa mga pasyenteng sumasailalim sa joint replacement na pumupunta sa panahon ng taglamig [1]. Kung sapat na ang iyong mga level, ang low-dose supplementation ay makakatulong sa iyo na mapanatili ang mga ito, habang ang mabababang level ay karaniwang nangangailangan ng medium-to-high doses upang maitama [2]. Ang pagpapanatili ng sapat na level ay maaari ring magpahusay sa long-term survival pagkatapos ng hip fracture surgery, kahit na hindi nito binabago ang iyong agarang paggaling [3].

Ang Vitamin D ay malamang na hindi para sa iyo kung normal na ang iyong mga level at wala kang nakaplano na gamutan, o kung umaasa ka ng garantisadong pagpapabilis ng paggaling. Hindi ito kapalit ng standard orthopaedic care, at ang mga peptide supplement ay hindi dapat gamitin bilang kapalit o kasabay nito, dahil wala pang mabuting data sa kaligtasan at efficacy para sa mga ito [4]. Ang mga mananaliksik ay bumubuo rin pa lamang ng mas mabubuting paraan upang i-track ang mga pinsala at problemang pangkalusugan sa mga babaeng atleta, na dapat magpahusay sa payo sa pag-iwas sa hinaharap [5].

Ang pagpili ay isang desisyong gagawin mo kasama ang iyong doktor. Susuriin nila ang iyong mga level, ang iyong nakaplanong gamutan, at ang iyong pangkalahatang kalusugan, pagkatapos ay tatalakayin kung makatwiran ba para sa iyo ang pag-test o supplementation. Ang mga posibleng downside ay nakasaad sa risks section sa itaas.

Ang pinaka-importante

Karapat-dapat suriin ang Vitamin D kung ikaw ay sasailalim sa operasyon o nagpapagaling mula sa isang fracture, dahil ang mababang antas nito ay maaaring matukoy sa pamamagitan ng blood test at magamot. Ang regular na supplementation ay nagbabawas ng pagkakataon ng deficiency sa mga pasyenteng sumasailalim sa joint replacement na pumupunta tuwing taglamig [1]. Kung sapat na ang iyong mga antas, ang mababang dose ay maaaring magpanatili nito, habang ang mababang antas ay karaniwang nangangailangan ng medium-to-high doses upang maitama [2]. Panatilihing makatotohanan ang iyong mga inaasahan: ang paggamot ay maaaring hindi magpabago sa iyong agarang paggaling, bagaman ang pagpapanatili ng sapat na antas ay maaaring makatulong sa mas mahabang panahon pagkatapos ng hip fracture surgery [3]. Ang pangunahing babala ay ang vitamin D ay hindi isang garantisadong lunas, at gumagana ito kasabay ng standard care sa halip na palitan ito.

Mga Sanggunian

[1] Ang Diagnosis ng Vitamin D Deficiency Ay Nauugnay sa Pagtaas ng Rate ng mga Anterior Cruciate Ligament Tear at Reconstruction Failure. Arthroscopy. 2023. DOI: 10.1016/j.arthro.2023.04.011

[2] Vitamin D at ang Panganib ng Stress Fracture sa mga Atleta at Military Personnel: Isang Systematic Review at Meta-analysis. The American Journal of Sports Medicine. 2026. DOI: 10.1177/03635465261441254

[3] Pagkalimot sa mga Frail: National Trends sa Vitamin D Prescription Pagkatapos ng Fragility Fracture—Isang Malaking Insurance Claims Database Study. Journal of the American Academy of Orthopaedic Surgeons. 2024. DOI: 10.5435/jaaos-d-23-00932

[4] Ang Epekto ng Serum Vitamin D Level sa Proseso ng Wound Healing Pagkatapos ng Open Carpal Tunnel Release Surgery: Clinical Outcomes ng 55 Kaso. Journal of the American Academy of Orthopaedic Surgeons. 2025. DOI: 10.5435/jaaos-d-25-00410

[5] Ang vitamin D deficiency ay nauugnay sa mga adverse medical outcome pagkatapos ng total shoulder arthroplasty. JSES International. 2025. DOI: 10.1016/j.jseint.2025.01.010

[6] Epekto ng Vitamin D Deficiency sa Short- at Long-Term Mortality sa mga Pasyenteng Sumasailalim sa Hip Fracture Surgery sa Ilalim ng General Anesthesia: Isang Matched Cohort Study. The Journal of Arthroplasty. 2025. DOI: 10.1016/j.arth.2025.04.080

[7] Ang Papel ng Vitamin D sa Postoperative Tendon Healing: Isang Scoping Review. Orthopaedic Journal of Sports Medicine. 2025. DOI: 10.1177/23259671251371300

[8] Epekto ng Vitamin D Supplementation sa Total Knee Arthroplasty Outcomes: Isang Systematic Review. Orthopaedic Journal of Sports Medicine. 2026. DOI: 10.1177/23259671261432670

[9] Ang preoperative serum vitamin D deficiency ay nauugnay sa pagtaas ng rotator cuff fatty degeneration ngunit malabong makaapekto sa post repair outcomes: isang systematic review at meta-analysis ng correlation coefficients. JSES Reviews, Reports, and Techniques. 2025. DOI: 10.1016/j.xrrt.2025.02.006

[10] Ang mga epekto ng pinagsamang calcium at vitamin D supplementation sa bone mineral density at fracture risk sa mga postmenopausal women na may osteoporosis: isang systematic review at meta-analysis ng randomized controlled trials. BMC Musculoskeletal Disorders. 2025. DOI: 10.1186/s12891-025-09089-7

[11] Vitamin D3 Supplementation Bago ang Total Knee Arthroplasty: Isang Randomized Controlled Trial. The Journal of Arthroplasty. 2023. DOI: 10.1016/j.arth.2022.08.020

[12] Ang Epekto ng Nanofiber-Based Vitamin D Sheet Para sa Tendon-To-Bone Healing at Muscle Regeneration sa Isang Rabbit Rotator Cuff Tear Model. Journal of Shoulder and Elbow Surgery. 2023. DOI: 10.1016/j.jse.2023.02.077

[13] Ang Vitamin D Supplementation ay Maaaring Makapigil o Makagamot sa Deficiency Pagkatapos ng Total Knee Arthroplasty: Isang Retrospective Cohort Analysis. Journal of the American Academy of Orthopaedic Surgeons. 2024. DOI: 10.5435/jaaos-d-24-00005

[14] 25-Hydroxyvitamin D Levels, Free Serum Calcium, Glomerular Filtration Rate, Albumin, at Femoral Fracture Elderly Patient Mortality. JAAOS: Global Research and Reviews. 2026. DOI: 10.5435/jaaosglobal-d-25-00108

[15] Peptide Supplements at ang Kanilang Therapeutic Applications sa Sports Medicine. The American Journal of Sports Medicine. 2026. DOI: 10.1177/03635465261464420

[16] Mas mataas na prevalence ng vitamin D deficiency sa mga arthroplasty patient na dumating tuwing taglamig. Journal of Orthopaedic Surgery and Research. 2025. DOI: 10.1186/s13018-025-06482-9

[17] Female athlete health domains: isang supplement sa International Olympic Committee consensus statement sa mga metodo para sa pag-record at pag-uulat ng epidemiological data sa injury at illness sa sport. British Journal of Sports Medicine. 2023. DOI: 10.1136/bjsports-2022-106620

Evidence & references

This is the clinical evidence summary written for health professionals. It is technical, and it lists the research this page was built from. You do not need to read it to understand your treatment or to make a decision about it.

Overview

A diagnosis of vitamin D deficiency is associated with increased rates of anterior cruciate ligament tears and reconstruction failure [2].
Vitamin D status should be assessed in high-risk populations to guide preventive strategies focused on maintaining optimal levels regarding the risk of stress fractures in athletes and military personnel [3].
Educational initiatives and revised guidelines may have improved vitamin D prescription rates after fragility fracture, but there is a need to raise awareness about the importance of vitamin D for bone health, particularly in older adults [4].
Vitamin D represents a potentially modifiable risk factor that could be optimized during both surgical and nonsurgical management of patients with Charcot arthropathy [5].
Regular vitamin D supplementation significantly reduces the likelihood of deficiency among arthroplasty patients presenting in winter [6].
Evidence suggests vitamin D may support tendon healing, particularly in rotator cuff repair, although studies remain low quality and limited to a single tendon group [7].
Preoperative vitamin D screening and potential supplementation strategies are important for patients who have vitamin D levels below 20 ng/mL undergoing hip fracture surgery under general anesthesia [8].
Hand grip strength, vitamin D status, and diets might be considered diagnostic non-invasive predictors of bone health for clinical use in epidemiological contexts in 6–12 years old school children [25].

How It Works

Bone Health and Fracture Risk

Vitamin D deficiency is associated with increased rates of anterior cruciate ligament tears and reconstruction failure [2].
Vitamin D status should be assessed in high-risk populations to guide preventive strategies focused on maintaining optimal levels for stress fracture risk [3].
Educational initiatives and revised guidelines may have improved vitamin D prescription rates after fragility fracture, but awareness of its importance for bone health in older adults needs to be raised [4].
Preoperative vitamin D screening and potential supplementation strategies are important for patients who have vitamin D levels below 20 ng/mL to address short- and long-term mortality risks after hip fracture surgery [8].
Active vitamin D3 treatment promoted fracture healing by affecting the levels of immune factors in osteoporotic fracture patients [17].

Tendon and Soft Tissue Healing

Evidence suggests vitamin D may support tendon healing, particularly in rotator cuff repair, though studies remain low quality and limited to a single tendon group [7].
Preoperative nonselective vitamin D supplementation appears to be more cost-effective than selective supplementation in arthroscopic rotator cuff repair, likely due to the lower cost of 25(OH)D supplementation compared to serum assays [9].
Combining systemic and localized vitamin D delivery significantly enhanced tendon-to-bone healing, muscle regeneration, and biomechanical strength in a rabbit rotator cuff tear model compared to other treatment groups [19].
Further research is necessary to elucidate the direct role of vitamin D in the pathogenesis of rotator cuff tears and its impact on clinical outcomes after rotator cuff surgery and total shoulder arthroplasty [20].

Wound Healing and Infection

Administering an oral 300,000 U single-dose vitamin D regimen to correct vitamin D deficiency can positively impact outcomes following primary total joint arthroplasty [10].
Determining vitamin D levels preoperatively and providing supplementation if deficiency is present may be beneficial for preventing delayed wound healing after open carpal tunnel release surgery [12].

Immune Modulation and Other

Supplementation with vitamin D 10,000 IU/day for 8 weeks can increase vitamin D levels >50 ng/dl to optimally act as an immunomodulator in tuberculosis spondylitis patients [15].
Targeted interventions are needed to optimize musculoskeletal and metabolic health in adolescents with vitamin D deficiency and adverse body composition [13].

What the Evidence Shows

Fracture and Bone Health

Sixteen weeks of high-intensity interval training and vitamin D consumption showed greater benefits for bone mineral density levels in women with osteoporosis than either vitamin D consumption or high-intensity interval training alone [16].
Maintaining adequate vitamin D levels may improve longer-term survival after proximal femoral fracture surgery, although vitamin D status alone may not influence immediate recovery [22].

Arthroplasty and Joint Surgery

Preoperative vitamin D screening and potential supplementation strategies are important for patients with vitamin D levels below 20 ng/mL undergoing hip fracture surgery under general anesthesia [8].
Low-dose vitamin D supplementation was beneficial for vitamin D–sufficient total knee arthroplasty patients to achieve higher levels and maintain sufficiency [21].
Deficient total knee arthroplasty patients benefited from medium-to-high dose vitamin D supplementation, though only 33.7% achieved repletion [21].
Perioperative vitamin D supplementation may enhance early recovery and lower complication rates after total knee arthroplasty [23].
Supplementation with 50,000 international units of vitamin D3 on the day of surgery failed to demonstrate statistically significant differences in functional Knee Society Score, Timed Up and Go Test times, or complications in the early postoperative period compared to placebo in total knee arthroplasty patients [24].

Tendon and Soft Tissue Healing

Nonselective vitamin D supplementation appears to be more cost-effective than selective supplementation for arthroscopic rotator cuff repair, likely due to the lower cost of 25(OH)D supplementation compared to serum assays [9].

Other Musculoskeletal Conditions

Research Gaps and Limitations

More research is needed to determine the effect of vitamin D supplementation on bone health and injury risk in elite athletes [1].

Practical Considerations

Screening and Assessment

Vitamin D status should be assessed in high-risk populations to guide preventive strategies focused on maintaining optimal levels [3].
Preoperative vitamin D screening is important for patients who have vitamin D levels below 20 ng/mL [8].
Vitamin D deficiency is associated with adverse medical outcomes following total shoulder arthroplasty [18].
Vitamin D deficiency is associated with increased rates of readmission and periprosthetic fractures following total shoulder arthroplasty [18].
Higher prevalence of vitamin D deficiency is observed among arthroplasty patients presenting in winter [6].

Supplementation and Management

Regular vitamin D supplementation significantly reduces the likelihood of deficiency [6].
Nonselective preoperative vitamin D supplementation appears to be more cost-effective than selective supplementation in arthroscopic rotator cuff repair [9].
The lower cost of 25(OH)D supplementation compared to serum assays likely contributes to the cost-effectiveness of nonselective preoperative supplementation in arthroscopic rotator cuff repair [9].

Evidence Limitations and Contraindications

Evidence suggests vitamin D may support tendon healing, particularly in rotator cuff repair, but studies remain low quality and limited to a single tendon group [7].
Peptide supplements should not currently be recommended as a replacement or adjunct for existing orthopaedic standard of care due to the lack of robust efficacy and safety data [11].

Key Evidence

[L1] More research is needed to determine the effect of vitamin D supplementation on bone health and injury risk in this population. [1] (10.1177/23259671231220371)
[L3] These results identify a population with increased odds of injury and provide valuable knowledge as we expand our understanding of the relationship between vitamin D and musculoskeletal health. [2] (10.1016/j.arthro.2023.04.011)
[L3] These findings suggest that vitamin D status should be assessed in high-risk populations to guide preventive strategies focused on maintaining optimal levels. [3] (10.1177/03635465261441254)
[L3] Educational initiatives and revised guidelines may have improved prescription rates, but there is a need to raise awareness about the importance of vitamin D for bone health, particularly in older adults. [4] (10.5435/jaaos-d-23-00932)
[L4] Vitamin D represents a potentially modifiable risk factor that could be optimized during both surgical and nonsurgical management of patients with Charcot arthropathy. [5] (10.5435/jaaosglobal-d-22-00162)
[L3] Regular vitamin D supplementation significantly reduces the likelihood of deficiency. [6] (10.1186/s13018-025-06482-9)
[L4] Although evidence suggests vitamin D may support tendon healing, particularly in rotator cuff repair, studies remain low quality and limited to a single tendon group. [7] (10.1177/23259671251371300)
[L2] These findings highlight the importance of preoperative vitamin D screening and potential supplementation strategies for patients who have vitamin D levels below 20 ng/mL. [8] (10.1016/j.arth.2025.04.080)
[L4] Nonselective supplementation appears to be more cost-effective than selective supplementation, likely due to the lower cost of 25(OH)D supplementation compared to serum assays. [9] (10.1016/j.jse.2023.05.007)
[L3] Administering an oral 300,000 U single-dose vitamin D regimen to correct vitamin D deficiency can positively impact outcomes following primary TJA. [10] (10.1016/j.arth.2024.05.012)
[L5] Because of the lack of robust efficacy and safety data, peptide supplements should not currently be recommended as a replacement or adjunct for existing orthopaedic standard of care. [11] (10.1177/03635465261464420)
[L3] Determining vitamin D levels preoperatively and providing supplementation if deficiency is present may be beneficial for preventing delayed wound healing. [12] (10.5435/jaaos-d-25-00410)
[L3] These findings highlight the need for targeted interventions to optimize musculoskeletal and metabolic health during this developmental window. [13] (10.1186/s13018-025-06091-6)
[L1] Supplementation with vitamin D 10,000 IU/day for 8 weeks can increase vitamin D levels >50 ng/dl to optimally act as an immunomodulator. [15] (10.1186/s13018-023-04445-6)
[L1] Sixteen weeks of HIIT and vitamin D consumption showed greater benefits for BMD levels in women with osteoporosis than either vitamin D consumption or HIIT training alone. [16] (10.1186/s12891-025-08275-x)
[L2] Active vitamin D3 treatment promoted fracture healing by affecting the levels of these immune factors. [17] (10.1186/s13018-023-03777-7)
[L3] The observed association between vitamin D deficiency and increased rates of readmission and periprosthetic fractures suggests that addressing vitamin D levels may be linked to reduced future healthcare utilization. [18] (10.1016/j.jseint.2025.01.010)
[L5] Combining systemic and localized vitamin D delivery significantly enhanced tendon-to-bone healing, muscle regeneration, and biomechanical strength in a rabbit rotator cuff tear model compared to other treatment groups. [19] (10.1016/j.jse.2025.12.003)
[L4] Further research is necessary to elucidate the direct role of vitamin D in the pathogenesis of rotator cuff tears and its impact on clinical outcomes after rotator cuff surgery and total shoulder arthroplasty. [20] (10.5397/cise.2024.00220)
[L3] Low-dose vitamin D supplementation was beneficial for vitamin D–sufficient TKA patients to achieve higher levels and maintain sufficiency, while deficient patients benefitted from medium-to-high dose supplementation, though only 33.7% achieved repletion. [21] (10.5435/jaaos-d-24-00005)
[L2] Although vitamin D status alone may not influence immediate recovery, maintaining adequate levels may improve longer term survival after PFF surgery. [22] (10.5435/jaaosglobal-d-25-00108)
[L2] Our study demonstrated that perioperative vitamin D supplementation may enhance early recovery and lower complication rates after TKA. [23] (10.1177/23259671261432670)
[L1] Supplementation with 50,000 international units vitamin D3 on the day of surgery failed to demonstrate statistical significant differences in functional KSS, TUGT times, or complications in the early postoperative period compared to placebo. [24] (10.1016/j.arth.2022.08.020)
[L4] These parameters might be considered diagnostic non-invasive predictors of bone health for clinical use in epidemiological contexts. [25] (10.1186/s12891-023-06960-3)

References

[1] Effects of Vitamin D Supplementation in Elite Athletes: A Systematic Review. Orthopaedic Journal of Sports Medicine. 2024. DOI: 10.1177/23259671231220371

[2] A Diagnosis of Vitamin D Deficiency Is Associated With Increased Rates of Anterior Cruciate Ligament Tears and Reconstruction Failure. Arthroscopy. 2023. DOI: 10.1016/j.arthro.2023.04.011

[3] Vitamin D and the Risk of Stress Fractures in Athletes and Military Personnel: A Systematic Review and Meta-analysis. The American Journal of Sports Medicine. 2026. DOI: 10.1177/03635465261441254

[4] Forgetting the Frail: National Trends in Vitamin D Prescription After Fragility Fracture—A Large Insurance Claims Database Study. Journal of the American Academy of Orthopaedic Surgeons. 2024. DOI: 10.5435/jaaos-d-23-00932

[5] Prevalence of Vitamin D Deficiency in Patients With Charcot Arthropathy: A Single-Center Analysis. JAAOS: Global Research and Reviews. 2022. DOI: 10.5435/jaaosglobal-d-22-00162

[6] Higher prevalence of vitamin D deficiency among arthroplasty patients presenting in winter. Journal of Orthopaedic Surgery and Research. 2025. DOI: 10.1186/s13018-025-06482-9

[7] The Role of Vitamin D in Postoperative Tendon Healing: A Scoping Review. Orthopaedic Journal of Sports Medicine. 2025. DOI: 10.1177/23259671251371300

[8] Impact of Vitamin D Deficiency on Short- and Long-Term Mortality in Patients Receiving Hip Fracture Surgery Under General Anesthesia: A Matched Cohort Study. The Journal of Arthroplasty. 2025. DOI: 10.1016/j.arth.2025.04.080

[9] Preoperative vitamin D supplementation is a cost-effective intervention in arthroscopic rotator cuff repair. Journal of Shoulder and Elbow Surgery. 2023. DOI: 10.1016/j.jse.2023.05.007

[10] Effect of Vitamin D Deficiency on Periprosthetic Joint Infection and Complications After Primary Total Joint Arthroplasty. The Journal of Arthroplasty. 2024. DOI: 10.1016/j.arth.2024.05.012

[11] Peptide Supplements and Their Therapeutic Applications in Sports Medicine. The American Journal of Sports Medicine. 2026. DOI: 10.1177/03635465261464420

[12] The Effect of Serum Vitamin D Level on Wound Healing Process After Open Carpal Tunnel Release Surgery: Clinical Outcomes of 55 Cases. Journal of the American Academy of Orthopaedic Surgeons. 2025. DOI: 10.5435/jaaos-d-25-00410

[13] Vitamin D deficiency and adverse body composition in adolescents. Journal of Orthopaedic Surgery and Research. 2025. DOI: 10.1186/s13018-025-06091-6

[15] Randomized controlled trial of vitamin d supplementation on toll-like receptor-2 (tlr-2) and toll-like receptor-4 (tlr-4) in tuberculosis spondylitis patients. Journal of Orthopaedic Surgery and Research. 2023. DOI: 10.1186/s13018-023-04445-6

[16] Concurrent effects of high-intensity interval training and vitamin D supplementation on bone metabolism among women diagnosed with osteoporosis: a randomized controlled trial. BMC Musculoskeletal Disorders. 2025. DOI: 10.1186/s12891-025-08275-x

[17] Determination of immune factor levels in serum and local hematoma samples of osteoporotic fracture patients and clinical study of the effect of active vitamin D3 treatment on immune factor levels. Journal of Orthopaedic Surgery and Research. 2023. DOI: 10.1186/s13018-023-03777-7

[18] Vitamin D deficiency is associated with adverse medical outcomes following total shoulder arthroplasty. JSES International. 2025. DOI: 10.1016/j.jseint.2025.01.010

[19] Localized vitamin D delivery via 3D-printed nanofiber sheets combined with systemic supplementation enhances tendon-to-bone healing in a rabbit rotator cuff tear model: a preclinical study. Journal of Shoulder and Elbow Surgery. 2026. DOI: 10.1016/j.jse.2025.12.003

[20] The role of vitamin D in shoulder health: a comprehensive review of its impact on rotator cuff tears and surgical results. Clinics in Shoulder and Elbow. 2024. DOI: 10.5397/cise.2024.00220

[21] Vitamin D Supplementation May Prevent or Treat Deficiency After Total Knee Arthroplasty: A Retrospective Cohort Analysis. Journal of the American Academy of Orthopaedic Surgeons. 2024. DOI: 10.5435/jaaos-d-24-00005

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